Cordeliers Research Center

Simplified studies through automated and reproducible image analysis algorithms

The Centre de Recherche des Cordeliers (CRC) has 450 employees whose aim is to study the coordination of the major functions of organisms and the role that the disruption of these functions has in the genesis and progression of diseases.

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The close relationship between fundamental and clinical research is a particular feature of the Center. The teams at the CRC also contribute to innovation in the areas of imaging, the identification of genetic, protein or cellular prognostic markers and the production of molecules or cells for therapeutic use. As part of their ongoing work, researchers quantify biomarkers over a large number of slides. In order to improve digital imaging within teams and to perfect analysis, researchers wanted to incorporate new digital pathology technology into their laboratory.

The solution :

The CRC is now quipped with digital slide scanners to help develop the automation process and the reproducibility of image analysis. CaloPix was program for use and enables image flows to be processed, from production and data analysis to overall management. Thanks to its database network function, CaloPix ensures optimal circulation of image data. The software is compliant with the security and traceability of data. A veritable workspace for researchers with ergonomic and powerful functionalities, CaloPix incorporates batch-by-batch processing and image tracking tools.

CaloPix ensures optimal circulation of image data. The software is compliant with the security and traceability of data. A veritable workspace for researchers with ergonomic and powerful functionalities, CaloPix incorporates batch-by-batch processing and image tracking tools.

Benefits :

  • Daily pratices improvement
  • Quantification work automatization
  • Data and all images centralization

Research has led to the publication of numerous studies into immune cells in cases of colorectal and lung cancer. So many new tools assisting the daily work of researchers and improving their practice.

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Users testify :

Dr Marie-Caroline Dieu-Nosjean
Researcher («Cancer and Anti-tumour Immunity» Laboratory , UMRS1138, CRC)

« In the main, we apply dual marking for the more accurate identification of the tissular location of cells of interest (e.g.: T lymphocytes within or outside tumour cell masses), an under-population of a given cell type (e.g.: regulating T lymphocytes among T CD4+ cells) or the potential function of a cell population (e.g.: T lymphocytes with cytotoxic activity among T CD8+ lymphocytes). We then need to quantify the positive cells for a given marker in the various tissue zones. The combination of these tasks involves lengthy and painstaking work which, if undertaken manually, also raises problems of inter- experimenter reproducibility. »

« The CaloPix software solution deployed by TRIBVN has allowed us to speed up the analysis and quantification of cells in a large series of images by the automation of tasks with low added value, and by the standardization of daily production on a virtual slide model. »

« For this reason, the introduction of reprodu- cibility in image analysis is reflected in improvements in the speed and efficiency of our research projects. »

« This integration permits the straightforward and graphic deployment of analysis macros on slides, indexing, presentation of results and the serial proces- sing of slides. The Morphometry and Tissue Recognition analysis macros in particular are used by our researchers. »

« This option for tailor-made and cost-free develop- ment has been a really decisive factor in our preference for the company TRIBVN